Bacterial mutagenicity of polycyclic aromatic hydrocarbons in reconstituted mixtures and crude coal tar extracts and fractions /
:4-, and 2-:4-ring mixtures. The 2-:4-ring, and 3-:4-ring
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1994.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | :4-, and 2-:4-ring mixtures. The 2-:4-ring, and 3-:4-ring 935 net revertants, while the benzo[a]pyrene:reconstituted additive responses. These data indicate that mixtures of Although polycyclic aromatic hydrocarbons (PAHS) are one of and an environmental crude coal tar extract and its and TAIOO. The reconstituted mixture elicited the maximum and total reconstituted groups in the same percentages as a assessment of complex PAH mixtures utilizes toxic equivalency At the four lower dose levels (0.09mg/mL to 1.8mg/mL), the chemicals with a reconstituted coal tar extract induced combinations induced lower mutagenic responses than the 4- consecutive dose levels with and without metabolic activation establishing a clearer understanding of risks and extract of a coal tar induced 385 net TA98 and 589 net TAIOO factors which assume additive interactions between individual fractions. The PAH mixtures were prepared in 2-, 3-, 4-ring from the coal tar extract and binary mixtures of individual groups of samples included PAH mixtures modeling a coal tar in the Salmonella/microsome assay using tester strains TA98 Inhibition was also observed when benzo[a]pyrene was tested interactions which occur from exposure to PAHS. interactive responses appear controlled by concentration and investigated using the Salmonellalmicrosome assay. Two known regarding their potential mutagenic interactions. Risk levels, with inhibition at higher doses. The mutagenicity of metabolism of the PAHS. Research of this nature may aid in mixture induced 349 net revertants. The methylene chloride mixture. At the highest dose level (18mg/mL), the model coal tar. The environmental coal tar was extracted and mutagenic response of 1,089 revertants at a dose of 1.8mg/mL. PAHs exhibit a variety of mutagenic interactions. The PAHS. The mutagenic interactions of PAH mixtures were reconstituted induced a higher response than the 4-ring reconstituted showed a lower response that the 4-ring. These results suggest enhanced mutagenic responses at lower dose revertants with high metabolic activation (30%). Fractions ring alone, suggesting inhibition by the 2- and 3-ring PAHS. separated into PAH fractions. Each sample was tested at 5 the most ubiquitous carcinogens in the environment, little is the PAH mixtures was evaluated in combinations as 2-:3-, 3- |
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| Item Description: | "Major subject: Toxicology". Vita. |
| Physical Description: | x, 94 leaves : illustrations ; 28 cm. Also available online. |
| Bibliography: | Includes bibliographical references. |