rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Pharmacokinetics of ranitidine HCL in horses and foals
  name:
    name part: Holland, Patricia Susan.
    role:
      role term: creator
  type of resource: text
  genre: bibliography
  origin info:
    place:
      place term: xx
    date issued: 1995
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    form: remote
    extent: xii, 75 leaves : illustrations ; 28 cm.
  abstract: 108.9 min; and Cl, 13.3 ml/min/kg. Following PO
  abstract: 126,413 ng-min/ml; AUMC, 18,038,825 ng-min2/ml; MAT, 32.0
  abstract: 3,266 ng/ml at 5 minutes to 11 ng/ml at 720 minutes after
  abstract: 99.2 min; Cmax, 237.2 ng/ml; and F, 27%. In foals,
  abstract: administration, a two-exponent equation, [] best described
  abstract: administration, a two-exponent equation, [], best described
  abstract: administration. A three-exponent equation, [] best described
  abstract: administration. The profile of the plot of concentrations of
  abstract: after intravenous (IV) and oral (PO) administration of drug
  abstract: AUC, 167,442 ng-min/ml; AUMC, 18,068,221 ng-min/ml; MRT,
  abstract: best described by a three-exponent equation. Mean values of
  abstract: concentrations of ranitidine HCl declined from a mean of
  abstract: Concentrations of ranitidine were determined using normal
  abstract: data for all horses. Mean values for model-independent
  abstract: date for five foals; data for the remaining foal were best
  abstract: described by a three-exponent equation. Mean values of the
  abstract: equation for two foals; data for the remaining four foals
  abstract: min; Tmax, 57.2 min; Cmax, 635.7 ng/ml; and F, 38%.
  abstract: min2/ml; MRT, 112.6 min; and Cl, 9.8 ml/min/kg. Following PO
  abstract: minutes to 37 ng/ml at 720 minutes after intravenous
  abstract: ng-min/ml; AUMC, 10,617,263 ng-min2/ml; MAT, 58.9 min; Tmax,
  abstract: pharmacokinetic values from the PO study include: AUC,
  abstract: pharmacokinetic values from the PO study include: AUC, 59,916
  abstract: phase high performance liquid chromatography. Adult horses
  abstract: Plasma pharmacokinetics of ranitidine HCl were investigated
  abstract: ranitidine HCl declined from a mean of 5,175 ng/ml at 5
  abstract: ranitidine HCl vs. time was best described by a two-exponent
  abstract: ranitidine/kg PO. In adult horses, plasma concentrations of
  abstract: received 2.2 mg/kg ranitidine PO and IV. Twelve- to sixteen-
  abstract: the data for five horses; data for the remaining horse were
  abstract: to six healthy adult horses and six healthy foals.
  abstract: values calculated from the last quantifiable time point were:
  abstract: values for model-independent values were: Vdss, 1.46 L/kg;
  abstract: Vdss, 1.07 L/kg; AUC, 231,126 ng-min/ml; AUMC, 26,970,792 ng-
  abstract: week-old foals received 2.2 mg ranitidine/kg IV and 4.4 mg
  abstract: were best described by a three-exponent equation. Mean
  note: by Patricia Susan Holland.
  note: "Major subject: Veterinary Medicine and Surgery".
  note: Vita.
  note: Also available online.
  note: Issued also on microfiche from Lange Micrographics.
  note: M.S. Texas A&M University 1995.
  note: Includes bibliographical references.
  subject:
    topic: Major veterinary medicine and surgery
  identifier: https://hdl.handle.net/1969.1/ETD-TAMU-1995-THESIS-H644
  related item:
    location:
      url: https://hdl.handle.net/1969.1/ETD-TAMU-1995-THESIS-H644
  record info:
    record content source: TXA
    record creation date: 960724
    record change date: 20220103134226.0
    record identifier: in00001306499