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Pharmacokinetics of ranitidine HCL in horses and foals /

108.9 min; and Cl, 13.3 ml/min/kg. Following PO

Bibliographic Details
Main Author: Holland, Patricia Susan
Format: Thesis eBook
Language:English
Published: [Place of publication not identified] : [publisher not identified] ; 1995.
Subjects:
Major veterinary medicine and surgery.
Online Access:Link to OAKTrust copy
Description
Summary:108.9 min; and Cl, 13.3 ml/min/kg. Following PO
126,413 ng-min/ml; AUMC, 18,038,825 ng-min2/ml; MAT, 32.0
3,266 ng/ml at 5 minutes to 11 ng/ml at 720 minutes after
99.2 min; Cmax, 237.2 ng/ml; and F, 27%. In foals,
administration, a two-exponent equation, [] best described
administration, a two-exponent equation, [], best described
administration. A three-exponent equation, [] best described
administration. The profile of the plot of concentrations of
after intravenous (IV) and oral (PO) administration of drug
AUC, 167,442 ng-min/ml; AUMC, 18,068,221 ng-min/ml; MRT,
best described by a three-exponent equation. Mean values of
concentrations of ranitidine HCl declined from a mean of
Concentrations of ranitidine were determined using normal
data for all horses. Mean values for model-independent
date for five foals; data for the remaining foal were best
described by a three-exponent equation. Mean values of the
equation for two foals; data for the remaining four foals
min; Tmax, 57.2 min; Cmax, 635.7 ng/ml; and F, 38%.
min2/ml; MRT, 112.6 min; and Cl, 9.8 ml/min/kg. Following PO
minutes to 37 ng/ml at 720 minutes after intravenous
ng-min/ml; AUMC, 10,617,263 ng-min2/ml; MAT, 58.9 min; Tmax,
pharmacokinetic values from the PO study include: AUC,
pharmacokinetic values from the PO study include: AUC, 59,916
phase high performance liquid chromatography. Adult horses
Plasma pharmacokinetics of ranitidine HCl were investigated
ranitidine HCl declined from a mean of 5,175 ng/ml at 5
ranitidine HCl vs. time was best described by a two-exponent
ranitidine/kg PO. In adult horses, plasma concentrations of
received 2.2 mg/kg ranitidine PO and IV. Twelve- to sixteen-
the data for five horses; data for the remaining horse were
to six healthy adult horses and six healthy foals.
values calculated from the last quantifiable time point were:
values for model-independent values were: Vdss, 1.46 L/kg;
Vdss, 1.07 L/kg; AUC, 231,126 ng-min/ml; AUMC, 26,970,792 ng-
week-old foals received 2.2 mg ranitidine/kg IV and 4.4 mg
were best described by a three-exponent equation. Mean
Item Description:"Major subject: Veterinary Medicine and Surgery".
Vita.
Physical Description:xii, 75 leaves : illustrations ; 28 cm.
Also available online.
Issued also on microfiche from Lange Micrographics.
Bibliography:Includes bibliographical references.