Age associated differences in response to lipopolysaccharide : central role of TNF /
accompanied by a decrease in the levels of cytokine
| Main Author: | |
|---|---|
| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1995.
|
| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | accompanied by a decrease in the levels of cytokine affording protection against lethal doses of LPS and this was aged mice. TNF production in response to sublethal doses of an experimental model of Sepsis to study the cause of this an increase in the levels of LPS binding proteins in these animals. Exogenous glucocorticoids were also effective in As Gram negative bacterial infection is a common cause of comparable levels in both age groups though the levels were cytokines namely IL-l(x and IFN-,Y seemed to have a lesser establishing the central role of TNF in the increased excessive production of TNF and the internal hormonal milieu groups, though for higher doses of LPS a siginificantly higher level of TNF was produced in the aged mice. Other increase in either the LPS receptor number on macrophages or increased lethality due to LPS in the older population. LPS did not show a significant difference between the two LPS observed in the aged animals seems to be primarily due to LPS seen in aged animals. Antibodies to TNF afforded maximized at a lower concentration of LPS in 24 mo old mo old), mature (12 mo old) and old (24 mo old) showed that natural inhibitors of cytokine production, were present at particular cytokine. produced equivalent amounts of cytokines. Glucocorticoids, production in these animals. Thus increased sensitivity to protection to aged animals given a supralethal dose of LPS response to LPS, the macrophages from the two age groups role to play than TNF in the age associated sensitivity to seems to have a definite effect on the overproduction of this sensitivity to LPS seen in the aged animals. In vitro, in septic shock in the older population in the U.S., we employed Studies on three different age groups of mice namely young (2 the older mice were about ten times more sensitive to LPS. This difference in response to LPS did not result from an |
|---|---|
| Item Description: | "Major subject: Microbiology". Vita. |
| Physical Description: | xi, 111 leaves : illustrations ; 28 cm. Also available online. Issued also on microfiche from Lange Micrographics. |
| Bibliography: | Includes bibliographical references. |