http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
pharmacokinetics of cuticular penetration of avermectin and decreased uptake resistance in the house fly, Mucsa domestica L
(L.), to examine the pharmacokinetics of cuticular
A study was conducted with the house fly, Musca domestics
amount of loss from the cuticular surface onto holding
and Cyro-R, a wild type strain with low level resistance to
avermectin associated with decreased insecticide uptake.
avermectin binding protein(s) appears to be responsible for
between strains. Interstrain differences were seen in the
briefly to avermectin residues on glass surfaces. Cuticular
containers following treatment, with the Cyro-R flies
decreased number of these transport proteins. The transport
Decreased uptake resistance may be associated with a
decreased uptake resistance to insecticides. The test
exhibiting 4X more. Loss of avermectin from the cuticular
following exposure to labeled glucose reduced [14C] buildup
in the cuticle, providing evidence the same transport
influx. The cuticular wax does not appear to play a critical
initial exposure. Specific binding of avermectin to proteins
Insecticide uptake was measured in adult flies exposed
insecticide was avermectin. Tritiated and nontritiated forms
mechanism was involved in hydrocarbon efflux and insecticide
natural function for a protein that facilitates insecticide
of [14C] incorporation into the wax. Exposure to avermectin
of a finite number of binding sites available for avermectin
of hydrocarbons to the cuticular surface appears to be a
penetration of insecticides and to elucidate the mechanism of
proteins was hypothesized for the differences seen between
quantitative change in the number of insecticide transport
radiolabeled glucose. Exposure was followed by measurements
role in insecticide uptake. A saturable high affinity
strains. To determine a natural function for an insecticide
surface was rapid, most occurring within 30 min following
susceptible flies following brief exposure to avermectin. A
transport mechanism, flies were exposed orally to [14C]
transporting avermectin from the waxes into the hemolymph.
uptake and quantitative differences in wax were not seen
uptake. More radioactivity was present in the hemolymph of
was higher in the susceptible strain, indicating the presence
waxes were not shown to play a critical role in insecticide
were used. Fly strains used were SBO, a multimutant (stubby
wing, brown body, ocra eye) insecticide susceptible strain