The pharmacokinetics of cuticular penetration of avermectin and decreased uptake resistance in the house fly, Mucsa domestica L. /
(L.), to examine the pharmacokinetics of cuticular
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| Format: | Thesis eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
[publisher not identified] ;
1994.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Summary: | (L.), to examine the pharmacokinetics of cuticular A study was conducted with the house fly, Musca domestics amount of loss from the cuticular surface onto holding and Cyro-R, a wild type strain with low level resistance to avermectin associated with decreased insecticide uptake. avermectin binding protein(s) appears to be responsible for between strains. Interstrain differences were seen in the briefly to avermectin residues on glass surfaces. Cuticular containers following treatment, with the Cyro-R flies decreased number of these transport proteins. The transport Decreased uptake resistance may be associated with a decreased uptake resistance to insecticides. The test entry. exhibiting 4X more. Loss of avermectin from the cuticular following exposure to labeled glucose reduced [14C] buildup in the cuticle, providing evidence the same transport influx. The cuticular wax does not appear to play a critical initial exposure. Specific binding of avermectin to proteins Insecticide uptake was measured in adult flies exposed insecticide was avermectin. Tritiated and nontritiated forms mechanism was involved in hydrocarbon efflux and insecticide natural function for a protein that facilitates insecticide of [14C] incorporation into the wax. Exposure to avermectin of a finite number of binding sites available for avermectin of hydrocarbons to the cuticular surface appears to be a penetration of insecticides and to elucidate the mechanism of proteins was hypothesized for the differences seen between quantitative change in the number of insecticide transport radiolabeled glucose. Exposure was followed by measurements role in insecticide uptake. A saturable high affinity strains. To determine a natural function for an insecticide surface was rapid, most occurring within 30 min following susceptible flies following brief exposure to avermectin. A transport mechanism, flies were exposed orally to [14C] transporting avermectin from the waxes into the hemolymph. uptake and quantitative differences in wax were not seen uptake. More radioactivity was present in the hemolymph of was higher in the susceptible strain, indicating the presence waxes were not shown to play a critical role in insecticide were used. Fly strains used were SBO, a multimutant (stubby wing, brown body, ocra eye) insecticide susceptible strain |
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| Item Description: | "Major subject: Entomology". Vita. |
| Physical Description: | xi, 61 leaves : illustrations ; 28 cm. Also available online. |
| Bibliography: | Includes bibliographical references. |