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mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Enzyme catalyzed oxido-reductive reactions
    sub title: synthetic applications and mechanistic studies
  name:
    name part: Fu, Hong
    name part: 1963-
    role:
      role term: creator
  name:
    name part: Fitzpatrick, Paul F.
    role:
      role term: degree committee member.
  name:
    name part: Harding, Kenn E.
    role:
      role term: degree supervisor.
  name:
    name part: Scott, A. Ian
    role:
      role term: degree committee member.
  name:
    name part: Wong, Kenn E.
    role:
      role term: degree supervisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: xx
    date issued: 1992
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xxii, 144 leaves : illustrations ; 28 cm
  abstract: Chapter II describes the synthetic application of a non-heme monooxygenase from Pseudomonas oleovorans (POM) toward the preparation of a series of epoxides from their protected allylic alcohol precursors. Like other monooxygenases, this enzyme system preferred hydrophobic substrates to hydrophilic substrates. The enantiomeric excess (ee) of the epoxide products depended on the shape of the substrates. The best ee value was found when the free hydroxy group of the allylic alcohol was protected with p-substituted phenyl or p-substituted benzyl group. Chapter III describes a mechanistic study of monooxygenases and their models. Several hypersensitive probes were designed for this purpose. A radical mechanism was proposed for the hydroxylation of a hypersensitive probe, fraras-2-phenyl-lmethylcyclopropane, catalyzed by POM since the only product obtained from the reaction was the ring-opened product. It was further supported by the fact that large intermolecular and intramolecular deuterium isotope effects are observed when deuterated probes were used as the substrates. In contrast, a concerted mechanism was proposed for the epoxidation of another hypersensitive probe, mzns-2-phenyl-lvinylcyclopropane, by two non-enzymic monooxygenase models because the epoxidation only occurred at the terminal vinyl group without the detection of any ring-opened products. Chapter IV describes utilizations of chloroperoxidase from Caldariomyces fumago in the synthesis of some highly optically pure sulfoxides, alcohols, and hydroperoxides. The stability study of this enzyme in organic solvent was also carried out. K[m] and V[max] of the substrates were determined and used as guidance for synthetic scale reactions to prevent the occurrence of the undesired nonenzymatic reaction. Chapter V describes the isolation, characterization, substrate specificity study and synthetic application of a new NADH dependent alcohol dehydrogenase from Pseudomonas sp. This unique enzyme catalyzes the reduct…
  note: "Major subject: Chemistry."
  note: Vita.
  note: Ph. D. Texas A & M University 1992
  note: Includes bibliographical references.
  subject:
    topic: Alcohol dehydrogenase
  subject:
    topic: Enzymes
    topic: Synthesis
  subject:
    topic: Epoxy compounds
    topic: Synthesis
  subject:
    topic: Organic compounds
    topic: Synthesis
  subject:
    topic: Sulfoxides
    topic: Synthesis
  subject:
    topic: Major chemistry
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-1450745
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-1450745
  record info:
    record content source: TXA
    record creation date: 941128
    record change date: 20220103134905.0
    record identifier: in00001208000
    language of cataloging:
      language term: eng