The effects of intraosseous hypertension and prostaglandin E₂ infusion in the tibia /
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| Other Authors: | , , , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
1991.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Abstract: | The effects of intraosseous hypertension and intraosseous infusion of Prostaglandin E2(PGE2) within the proximal tibial metaphysis of skeletally immature goats were evaluated. The mean baseline intraosseous pressure (IOP) measured at the proximal metaphysis was 15.65 +/- 3.38 mm Hg. The Osteoport implant was used to facilitate intraosseous infusions. Intraosseous hypertension (IH) was maintained (P < 0.05) within the proximal metaphysis for at least 10 days following creation of venous outflow obstruction (VOO) by ligation of the popliteal vein draining the proximal tibia and occlusion of the diaphyseal medullary space using bone cement. Continual intraosseous infusion (Cl) of autologous whole blood (mean 1.11 +/- 0.67 ml/min, group 1, and 17.04 +/- 2.63 ml/min, group 2) was used to maintain the IOP 2 to 3 times baseline values over a 5 day period. High-pressure infusion (HPI) using 5 ml of autogenous whole blood injected within a 5 second period, produced IOPs in excess of 6 times the baseline value. Elevations of the IOP greater than 2 times the baseline value (approximately 35 mm Hg) was associated with clinical evidence of bone pain. Continual IH resulted primarily in cancellous new bone formation (P < 0.05) within the metaphyseal marrow space and moderate increases in new bone at the periosteal and endocortical surfaces. High-pressure infusion (intermittent intraosseous hypertension) did not result in significant bone changes. The new bone formation associated with intraosseous hypertension may be the result of hydrostatically generated streaming potentials within the metaphysis. The intraosseous infusion of PGE2 produced a marked dose-dependent increase in new bone (P < 0.05) at both the periosteal and endocortical surfaces. These results do not support the current theory that PGE2 found within the fluid of unicameral bone cysts is responsible for maintenance of the cysts cavity. Intensive marrow fibrosis developed in all areas of increased bone remodeling. Subendosteal cysts developed within the marrow fibrous tissue in the PGE2 -VOO specimens. Seemingly, multinucleate giant cells and histiocytes may be associated with cyst formation. The significance of the subendosteal cysts is unknown. |
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| Item Description: | Typescript (photocopy). Vita. "Major subject: Veterinary Medical Sciences." |
| Physical Description: | xi, 94 leaves : illustrations ; 29 cm |
| Bibliography: | Includes bibliographical references. |