The chemistry of re(v)-oxo and nitrido complexes containing tetraazamacrocyclic or aromatic thiolato and amino ligands /
| Main Author: | |
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| Other Authors: | , , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
1991.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Abstract: | Recently, two isotopes of rhenium, [^186]Re and [^188]Re, have been found to possess desirable physical properties for utilization as radiopharmaceuticals. A need exists for radiopharmaceuticals in the form of small lipophilic metal complexes for imaging the brain and radioactively labelled biomolecules. While the chemistry of [^99m]Tc has been vigorously studied for these applications, the chemistry of Re has lapsed far behind. While structurally similar complexes are formed for the two metals, because of periodic differences, Re is harder to reduce and forms more robust complexes. Therefore, new synthetic strategies are needed. In this study, the syntheses of Re(V)-oxo complexes of neutral, mono-amide and diamide tetraazamacrocycles are presented as well as the x-ray structural studies of ReO(OH) (cyclam)^2+ and ReO(OH)(H[-1]-oxocyclam)+ . The additional anionic charge contributed by the deprotonation of the amide nitrogen causes some variations in the type of metal-oxo core of the complexes ranging from Re(V)O^3+ to Re(V)O2^+ . The Re(V)N^2+ complexes of the same macrocycles were also synthesized and investigated. The ligand exchange reactions between ReNCl2 (PPh3)2 and aromatic thiolate, amino and phenolate ligands were also investigated in an attempt to isolate neutral Re(V)N2+ species... |
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| Item Description: | Typescript (photocopy). Vita. "Major subject: Chemistry." |
| Physical Description: | xiv, 123 leaves : illustrations ; 29 cm |
| Bibliography: | Includes bibliographical references. |