Comparative mapping of homologous loci from four human chromosomes in the bovine /
| Main Author: | |
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| Other Authors: | , , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
1990.
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| Subjects: | |
| Online Access: | ProQuest, Abstract Link to OAKTrust copy |
| Abstract: | In order to construct a more detailed bovine syntenic map, 29 loci from four human chromosomes were physically mapped to their respective bovine syntenic groups. The four human chromosomes (HSA) chosen for study in the bovine were 1, 3, 10, and 21. HSA 3 and 21 loci have a special relationship in both the bovine and the mouse, and may have been ancestrally syntenic. The loci from these two human chromosomes exhibit a great deal of syntenic conservation in the bovine. In contrast, loci from HSA 1 and HSA 10 are each represented by at least three bovine chromosomes and are much less conserved syntenically. The ultimate goal of mapping in the bovine is the production of a linkage map useful for improved selection schemes. To this end loci from the U10 syntenic group (representing the HSA 21 and some of the HSA 3 loci) were evaluated for the presence of DNA variation. Such variation in the form of restriction fragments of variable size has been successfully used in human linkage map development. |
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| Item Description: | Typescript (photocopy). Vita. "Major subject: Genetics." |
| Physical Description: | x, 96 leaves : illustrations ; 29 cm |
| Bibliography: | Includes bibliographical references. |