Preparation, characterization and in vivo evaluation of two hemoglobin-based blood substitutes /

Bibliographic Details
Main Author:	Sheffield, Cynthia Lee, 1955-
Other Authors:	Corrier, Don (degree committee member.), Witzel, Don (degree committee member.)
Format:	Thesis Book
Language:	English
Published:	1990.
Subjects:	Blood substitutes > In vivo > Evaluation. Cattle > In vivo > Blood substitutes. Hemoglobin > Cattle > Analysis. Major veterinary physiology. Academic theses
Online Access:	Link to ProQuest copy Link to OAKTrust copy ProQuest, Abstract

Description
Abstract:	1. The controlled hypoosmotic dialysis ultrafiltration (CDU) system described in this work can be used to isolate large quantaties of ultrapure, lipid-free hemoglobin from the red blood cells of a variety of mammals. 2. A nonantigenic blood substitute with a intravenous retention time of at least 14 days can be produced by polymerization of bovine hemoglobin isolated by CDU. 3. The P50 of polymerized bovine hemoglobin can be returned to levels equivalent to that of bovine whole blood by binding IHP to the polyhemoglobin. 4. IHP modified polymerized bovine hemoglobin is not a suitable blood substitute material.
Item Description:	"Major subject: Veterinary physiology." Typescript (photocopy). Vita.
Physical Description:	viii, 106 leaves : illustrations ; 29 cm
Bibliography:	Includes bibliographical references.