rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Genomic analysis of the major bovine milk protein genes
    sub title: implications for the evolution of mammalian syntenic groups
  name:
    name part: Threadgill, David Wayne
    name part: 1961-
    role:
      role term: creator
  name:
    name part: Womack, James E.
    role:
      role term: degree supervisor.
  name:
    name part: Gold, John R.
    role:
      role term: degree committee member.
  name:
    name part: Templeton, Joe W.
    role:
      role term: degree committee member.
  name:
    name part: Wild, James R.
    role:
      role term: degree committee member.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: xx
    date issued: 1989
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: x, 81 leaves : illustrations ; 29 cm
  abstract: The genomic arrangement of the major bovine milk protein genes has been determined using a combination of physical mapping techniques. The major milk proteins consist of the four caseins, α (subscript S1) (CASAS1), α (subscript S2) (CASAS2), β (CASB), and k (CASK), as well as the two major whey proteins, a-lactalbumin (LALBA) and (Hactoglobulin (LGB). A panel of bovine X hamster hybrid somatic cells analyzed for the presence or absence of bovine specific restriction fragments revealed the genes coding for the major milk proteins to reside on three chromosomes. The four caseins were assigned to syntenic group U15 with peptidase S (PEPS) and phosphoglucomutase 2 (PGM2) and localized to bovine chromosome 6 at q31-33 by in situ hybridization. LALBA segregated with the HSA 12 marker, glyceraldehyde-3-phosphate dehydrogenase (GAPD) of syntenic group U3, while LGB segregated with the HSA 9 marker, the ABL oncogene of syntenic group U16. Pulsed-field gel electrophoresis confirmed genetic mapping results indicating tight linkage of the casein genes. The four genes reside on less than 200kb of DNA in the order CASAS2-CASAS1- CASB-CASK. A syntenic analysis of HSA 9 and HSA 12 homologs in the bovine using bovine X hamster and bovine X mouse hybrid somatic cells was performed to determine the extent of genomic conservation surrounding (3-lactoglobulin and α-lactalbumin, respectively. The HSA 9 markers, Abelson murine leukemia viral oncogene homolog (ABL), argininosuccinate synthetase (ASS), and glucose regulated protein 78KD (GRP78) were assigned to syntenic group U16 while aldehyde dehydrogenase 1 (ALDH1), aldolase B (ALDOB), complement component 5 (C5), gelsolin (GSN), glycoprotein-4-beta-galactosyl-transferase 2 (GGTB2), and inter-alpha-trypsin inhibitor (ITI) were assigned to syntenic group U18. The HSA 12 loci, alpha-2-macroglobulin (A2M), glioma-associated oncogene homolog (GLI), homeo box region 3 (HOX3), murine virus tumor integration site oncogene homolog (INT1), Kirste…
  note: by David Wayne Threadgill.
  note: Typescript (photocopy).
  note: Vita.
  note: "Major subject: Genetics."
  note: Ph. D. Texas A & M University 1989
  note: Includes bibliographical references.
  subject:
    topic: Dairy cattle
    topic: Genetics
  subject:
    topic: Gene mapping
  subject:
    topic: Chromosome abnormalities
  subject:
    topic: Chromosome abnormalities
  subject:
    topic: Dairy cattle
    topic: Genetics
  subject:
    topic: Gene mapping
  subject:
    topic: Genetics
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  record info:
    record content source: TXA
    record creation date: 900725
    record change date: 20200904152456.0
    record identifier: in00000918283
    language of cataloging:
      language term: eng