Comparison of drug disposition in normal dogs and dogs with mild, moderate and severe liver disease /
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| Other Authors: | , , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
1989.
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| Subjects: | |
| Online Access: | Link to OAKTrust copy |
| Abstract: | The in vivo disposition of indocyanine green (ICE), antipyrine and caffeine and the in vitro activity of 7- ethoxycoumarin O-deethylase (ECOD) and testosterone hydroxylase (TTOT) and cytochrome P-450 content (P-450) were compared between normal dogs (Group 1) and dogs with mild (Group 2), moderate (Group 3) and severe (Group 4) dimethyInitrosamine-induced liver disease. Correlations were examined between in vivo and in vitro indices and clinical laboratory tests and histological lesions. Both in vivo and in vitro indices reflected decreased drug elimination in Groups 3 and 4 compared to Group 1. For ICG and antipyrine, half-life (HL), and mean residence time (MRT) were significantly greater and the elimination rate constant (KEL) and plasma clearance (CLR) were significantly less in Groups 3 and 4 compared to Group 1. For caffeine, CLR and KEL were significantly less in Group 3 compared to Group 1 and HL and MRT were significantly greater in Groups 3 and 4 compared to Groups 1 and 2. For in vitro assays, P-450 and TTOT were significantly less in Group 2 compared to Group 1 and in Groups 3 and 4 compared to Group 2. Groups 3 and 4 ECOD were significantly less than Groups 1 and 2. Groups 3 and 4 ECOD were significantly less than Groups 1 and 2. Several parameters of ICG, antipyrine and caffeine significantly correlated with one another; the closest correlations were between antipyrine and both ICG and caffeine. Of the in vitro assays, P-450 and TIOT were most closely correlated. The closest correlations between in vivo and in vitro indices were between P-450 and TTOT and both ICG and antiyprine.. |
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| Item Description: | Typescript (photocopy). Vita. "Major subject: Veterinary Physiology." |
| Physical Description: | xv, 246 leaves : illustrations ; 29 cm |
| Bibliography: | Includes bibliographical references. |