The disposition of selected antimicrobial agents in healthy and bronchopneumonic calves /
| Main Author: | |
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| Other Authors: | , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
1989.
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| Subjects: | |
| Online Access: | ProQuest, Abstract Link to OAKTrust copy |
| Abstract: | To study the effect of respiratory disease on the disposition of oxytetracycline, sulfadiazine and trimethoprim in calves it was necessary to develop a model for sampling drug concentration in the lung parenchyma and a technique for inducing a reproducible localized focal pneumonia. An implantable sachet was designed and surgically placed into the right anterior lobe of the lung. Use of a fiberoptic bronchoscope permitted the precise deposition of a logarithmic phase culture of Pasteurella haemolytica into the lung lobe containing the implant. Serial collections of pulmonary samples were made during the course of pharmacokinetic trials in healthy and bronchopneumonic calves. The implant and induction models required specialized facilities and were, therefore, most appropriately used for pilot studies. A comparison of the pharmacokinetics of oxytetracycline, sulfadiazine and trimethoprim in control, post-surgical and pneumonic calves revealed few significant changes. All of the tested drugs entered the implanted sachets but the results were inconsistent and the time versus concentration curves were not suitable for analysis using the available pharmacokinetic computer programs. Bronchopneumonia appeared to have only minimal effects on the disposition of oxytetracycline, sulfadiazine and trimethoprim in feeder calves. |
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| Item Description: | Typescript (photocopy). Vita. "Major subject: Veterinary Physiology." |
| Physical Description: | xiv, 171 leaves : illustrations ; 29 cm |
| Bibliography: | Includes bibliographical references. |