http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Mapping the human chromosome 11p syntenic group in cattle
Parathyroid hormone and the beta hemoglobin gene cluster, which are on the short arm of human chromosome 11, as well as the albino (c) locus, which is closely linked to beta hemoglobin in rats, cats, mice and rabbits, were mapped in cattle using a panel of hamster-bovine hybrid somatic cells. These hybrid cells had previously been used to map the enzymes lactate dehydrogenase A and catalase to different syntenic groups in cattle. Parathyroid hormone and the beta hemoglobin gene cluster were shown to be linked to each other and to be syntenic with catalase on group U20 showing conservation of part of the linkage group on human chromosome 11p. However, the c locus probe was syntenic with lactate dehydrogenase A on syntenic group U7 which is a departure from conservation. Four restriction fragment length polymorphisms each for parathyroid hormone and the beta hemoglobin gene cluster were used with 45 informative meioses in pedigreed cattle to determine the map distance between the two genes. The distance was found to be 15.6 [plus or minus] 5.4cM which is approximately twice that in humans (7cm). Two of the restriction fragment length polymorphisms for beta hemaglobin were in linkage disequilibrium with the electrophoretic polymorphisms for hemoglobin isozymes in the same cattle. The frequencies of parathyroid hormone and beta hemoglobin restriction fragment length polymorphisms in small groups of purebred Angus, Brahman, Herefords, Holsteins and Jerseys were significantly different from the frequencies in all cattle tested. Moreover, in the Brahmas (Bos indicus), the 23.7kb parathyroid hormone fragment is the most common. In other breeds (all Bos taurus) the 13.2kb fragment is the most common.
Includes bibliographical references (leaves 46-51).