rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Positive inotropic effects of morphine in isometric rat papillary muscle preparations following isolation in high magnesium cardioplegia
  name:
    name part: Wagner-Mann, Colette Carol
    name part: 1952-
    role:
      role term: creator
  name:
    name part: Gross, David R.
    role:
      role term: degree supervisor.
  name:
    name part: Amoss, Max S.
    role:
      role term: degree committee member.
  name:
    name part: Granger, Harris
    role:
      role term: degree committee member.
  name:
    name part: Hightower, Dan
    role:
      role term: degree committee member.
  name:
    name part: Hunter, Jon F.
    role:
      role term: degree committee member.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: xx
    date issued: 1988
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiii, 104 leaves : illustrations ; 29 cm
  abstract: Possible explanations for the positive inotropic effects of morphine on isometric rat papillary muscle preparations isolated in high magnesium cardioplegia were studied. Muscles isolated in high magnesium (32 mEq/L) cardioplegia then challenged with morphine (0.1 mg/ml) responded with an increase in peak developed tension (29% increase from baseline), unlike preparations isolated in balanced salt solution, where morphine (0.1 mg/ml) and magnesium (1.0 mEq/L) individually both caused a decrease in peak developed tension (13% and 16% decrease from baseline respectively). However the same concentrations of morphine and magnesium combined in balanced salt solution isolated preparations resulted in increased peak developed tension (22% increase from baseline). These phenomena were not unique to one set of concentrations tested. Proportionate decreases (by 11 percent) of morphine and magnesium resulted in increased peak developed tension (13% increase from baseline). Similarly, an 11% decrease of the magnesium in the isolation cardioplegia and an 11% decrease of the added morphine resulted in an average increase of 20% in peak developed tension from baseline. The use of the calcium channel blocker, verapamil (0.125 micrograms/ml), after isolation in the cardioplegia and prior to the addition of morphine (0.1 mg/ml) effectively blocked the positive inotropic response. Also, the T1/2 values (half-time of relaxation from peak tension) calculated from recorded tension responses in each of the experiments did not change from baseline, a pattern of response consistent with an agent which causes increased extracellular calcium concentration. The result is an increase in peak developed tension. It was concluded that morphine and magnesium preferentially complex with each other when combined. The morphine/magnesium complexing decreases the amount of magnesium available to antagonize calcium. The amount of calcium and morphine complexing is also decreased when morphine and magnesiu…
  note: Typescript (photocopy).
  note: Vita.
  note: "Major subject: Veterinary Physiology."
  note: Ph. D. Texas A & M University 1988
  note: Includes bibliographical references.
  subject:
    topic: Cardiotonic agents
  subject:
    topic: Morphine
    topic: Physiological effect
  subject:
    topic: Rats
    topic: Physiology
  subject:
    topic: Major veterinary physiology
  identifier: http://gateway.proquest.com/openurl
  identifier: http://hdl.handle.net/1969.1/Dissertations-791546
  identifier: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://hdl.handle.net/1969.1/Dissertations-791546
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: http://gateway.proquest.com/openurl
  record info:
    record content source: TXA
    record creation date: 890831
    record change date: 20190325092241.0
    record identifier: in00000781242
    language of cataloging:
      language term: eng