rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Catalysis of [beta]-elimination of amino acids by pyridoxal and metal ions
  name:
    name part: Tatsumoto, Kuniyasu.
    role:
      role term: creator
  name:
    name part: Martell, A. E.
    role:
      role term: degree supervisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: txu
    date issued: 1978
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiii, 121 leaves : illustrations, graphs ; 28 cm
  abstract: The kinetics and equilibrium measurements of a-amino acids have been investigated, under β-elimination conditions, in the presence of pyridoxal with and without catalytic metal ions. The nmr technique was applied to several pyridoxal-amino acid systems, β-chloroalanine, β-chloro-αobutyric acid, O-phosphoserine, S-ethylcysteine, β-phenylserine, and β-hydroxyglutamic acid, in order to determine reactivity, equilibria, and reaction kinetics. The order of the reaction rate for β-eliminotion, from the fastest to the slowest, is S-chloroalanine, O-phosphoserine, β- chloro-a-aminobutyric acid, and S-ethylcysteine. The differences in the rate constants showed that the most electronegative group is the best leaving group. The differences in the rate constants between β-chloroalanine and β-chloro- α -aminobutyric acid also showed the β-substituent effect. The experiment with β-phenylserine showed that more than one reaction is possible with β-hydroxy amino acid systems. Both β-elimination and dealdolation reactions were observed for β-phenylserine. The dealdolation reaction was the dominating reaction for this system. The β-hydroxyglutamic acid system not only showed that more than one reaction is possible, but showed that sequential reactions are possible. The main reactions were deaidolation and β -elimination reactions, and sequential reactions are β -elimination followed by decarboxylation. The above reactions point out the necessity of choosing the proper conditions in order to observe a particular reaction. The metal ion catalysis of the β -elimination reaction is very pronounced for ail the amino acids studied. The Ga(III) and Al(III) ions were shown to be more effective catalysts than Zn(II) ion. For the amino acids with more than one reaction, metal ions also showed considerable catalytic effect. The product ratio varied with the charges of the metal ions.
  note: by Kuniyasu Tatsumoto.
  note: "Major subject: Chemistry."
  note: Vita.
  note: Texas A & M University
  note: Includes bibliographical references (leaves 112-120).
  subject:
    topic: Chemical kinetics
  subject:
    topic: Deamination
  subject:
    topic: Chemistry
  subject:
    topic: Chemical kinetics
  subject:
    topic: Deamination
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-776551
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-776551
  record info:
    record content source: TXA
    record creation date: 790727
    record change date: 20220104090521.0
    record identifier: in00000771967
    language of cataloging:
      language term: eng