The effect of selected six-mercaptopurine metallo complexes upon purine metabolism in normal and tumor-bearing rats /
| Main Author: | |
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| Other Authors: | , , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
[College Station, Tex.] :
Skinner,
1980.
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| Subjects: | |
| Online Access: | Link to ProQuest copy Link to OAKTrust copy |
| Abstract: | The research described in this dissertation concerns the investigation of selected 6-mercaptopurine metallo complexes. Syntheses are developed, the compounds are screened for anti-carcinogenic activity in two in vivo leukemia systems and then are tested for their effects upon the activity of adenosine deaminase (E.C. 3.5.4.4) in rat tissues. A colorimetric assay is used, complemented by an enzyme peak-shift procedure using reversed-phase high pressure liquid chromatography. Treatment with these drugs is found to have no effect upon the activity of this enzyme in selected rat tissues. |
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| Item Description: | "Major subject: Biochemistry." Vita. |
| Physical Description: | ix, 88 leaves : illustrations, graphs ; 29 cm |
| Bibliography: | Includes bibliographical references (leaves 80-85). |