rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: effects of hymenoxon on glucose metabolism in rat brain
  name:
    name part: Roberts, Ann Jane.
    role:
      role term: creator
  name:
    name part: Camp, Bennie J
    role:
      role term: degree supervisor.
  name:
    name part: Crookshank, Herman R.
    role:
      role term: degree committee member.
  name:
    name part: Davis, Richard H.
    role:
      role term: degree committee member.
  name:
    name part: Russell, Leon H.
    role:
      role term: degree committee member.
  name:
    name part: Shaw, Emil G.
    role:
      role term: degree committee member.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: txu
    date issued: 1977
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiv, 132 leaves : illustrations ; 28 cm
  abstract: Hymenoxon is a toxic sesquiterpene lactone isolated from the range plant bitterweed (Hymenoxys odorata). Sheep, goats and cattle poisoned by ingestion of bitterweed have central nervous system (CNS) depression which, in time becomes severe and causes death. The lactone produces similar CNS depression and is toxic to sheep (intraperitoneal LD₅₀, 7mg/kg). The literature provides evidence that similar lactones of plant origin have growth inhibitory action against tumor systems. This action is attributed to the lactone reaction with essential sulfhydryl groups of phosphofructokinase causing inhibition of glucose metabolism. On the basis of this evidence and the CNS effects produced by bitterweed and hymenoxon, it was hypothesized that bitterweed is toxic to range animals because hymenoxon inhibits glucose metabolism in nervous tissue. Similar CNS depression has been reported in rats treated with hymenoxon. I found that one rat, under observation until it died 13 hr after intraperitoneal administration of 200 mg/kg of hymenoxon, had general depression. This rat became less reactive to external stimuli as time increased and was comatose at 10 hr. In order to establish the mode of action of hymenoxon, the effects of the bitterweed lactone on glucose metabolism in the brain was tested using the rat as the experimental animal. Neutral extracts from the brains of rats were analyzed spectrophotometrically for changes in glucose, glycolytic metabolite and sulfhydryl group concentrations in response to in vivo and in vitro exposure to hymenoxon..
  note: by Ann Jane Roberts.
  note: "Major subject: Veterinary Toxicology."
  note: Vita.
  note: Texas A & M University
  note: Includes bibliographical references (leaves 108-115).
  subject:
    topic: Actinea odorata
    topic: Toxicology
  subject:
    topic: Glucose
    topic: Metabolism
  subject:
    topic: Hymenoxon
    topic: Toxicology
  subject:
    topic: Rats
    topic: Physiology
  subject:
    topic: Veterinary Toxicology
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-621142
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-621142
  record info:
    record content source: TXA
    record creation date: 780627
    record change date: 20220104090220.0
    record identifier: in00000595654
    language of cataloging:
      language term: eng