The effect of exercise on the severity of isoproterenol-induced myocardial infarction /
| Main Author: | |
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| Other Authors: | , , |
| Format: | Thesis Book |
| Language: | English |
| Published: |
[College Station, Tex.] :
Riggs,
1976.
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| Subjects: | |
| Online Access: | Link to ProQuest copy Link to OAKTrust copy |
| Abstract: | The purpose of this investigation was to determine if trained and untrained rats would differ in response to isoproterenol-induced myocardial infarction. The objectives were to: (1) determine the effect of a thirty day training program on the severity of the myocardial infarct-like lesion produced by isoproterenol, (2) determine the effect of a thirty day training program on the serum creatine phosphokinase (CPK) activity response to isoproterenol-induced myocardial infarction, and (3) determine the effect of a thirty day training program on the mortality associated with isoproterenol-induced myocardial infarction. Procedures: Ninety-three male Sprague-Dawley rats were randomly divided into three experimental groups. The sedentary-isoproterenol group remained sedentary while animals in the exercise-isoproterenol group and the exercise control group exercised daily at one mile per hour and two percent grade for thirty days. Eight animals were randomly selected from an additional group of male Sprague-Dawley rats similar in age and weight to the experimental animals and served as the sedentary control group for histological comparisons. The animals of the sedentary control group were not exercised or injected. Pre-training body weights and serum CPK activity levels for animals in the three experimental groups were determined twenty-four hours prior to beginning the exercise program. Forty-eight hours following the fin al exercise period, post-training body weights were recorded and animals in the sedentary-isoproterenol and exercise-isoproterenol groups received a single, subcutaneous injection of isoproterenol (250 mg/kg body weight). Animals in the exercise control group received an injection of sterilized isotonic saline and animals in the sedentary control group were not injected.. |
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| Item Description: | "Major subject: Health and Physical Education." Vita. |
| Physical Description: | xii, 77 leaves : illustrations ; 28 cm |
| Bibliography: | Includes bibliographical references (leaves 69-75). |