Investigations into the hemodynamic and metabolic effects of fructose 1,6 diphosphate and prostacyclin in hypovolemic shock.

Bibliographic Details
Main Author:	Bland-van den Berg, Paul
Other Authors:	Green, R. A. (degree committee member.), Hightower, D. F. (degree committee member.)
Format:	Thesis Book
Language:	English
Published:	1982.
Subjects:	Fructose. Nucleotides > Metabolism. Prostacyclin. Shock. Veterinary Physiology Academic theses
Online Access:	Link to ProQuest Copy Link to OAKTrust copy

Description
Abstract:	A modified Wiggers canine hemorrhagic shock model was developed to evaluate the hypotheses that (1) irreversible shock is the result of depletion of tissue ATP levels below a critical point, following which failure of subcellular organelles, cell death, multisystem organ failure and death of the organism occur; (2) fructose 1,6 diphosphate (F1,6 DP) can increase tissue production of ATP by stimulating anaerobiosis; (3) prostacyclin (PGI(,2)) can increase tissue production of ATP by promoting aerobic metabolism through improved tissue blood flow and maintenance of subcellular compartmentalization; (4) the effects of F1,6DP and PGI(,2) may be additive or synergistic. ...
Item Description:	"Major subject: Veterinary Physiology." Typescript (photocopy). Vita.
Physical Description:	xv, 163 leaves : illustrations ; 29 cm
Bibliography:	Includes bibliographical references (leaves 110-128).