rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: In vivo transfer of immunity by the immunogenic RNA and determination of macrophage in the production of immunogenic RNA
  name:
    name part: Rao, Vijaya Balusu.
    role:
      role term: creator
  name:
    name part: Cox, E. R.
    role:
      role term: degree committee member.
  name:
    name part: Foster, B. G.
    role:
      role term: degree supervisor.
  name:
    name part: Hidalgo, R. J.
    role:
      role term: degree committee member.
  name:
    name part: Lewis, D. H.
    role:
      role term: degree committee member.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses.
  origin info:
    place:
      place term: txu
    date issued: 1977
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: viii, 56 leaves : illustrations ; 28 cm
  abstract: Immunogenic RNA and normal RNA were obtained by phenol extraction method from peritoneal exudate cells and spleen cells of outbred Swiss Webster and inbred BALB/c mice and the photometric studies were performed. The antigens used in the immunization procedures were sheep red blood cells and Streptococcus pneumoniae. In vitro studies were performed with the immunogenic RNA obtained from mice immune to sheep red blood cells. The type of antibodies produced in vitro were also determined. The in vivo comparison studies were performed using the immune whole cells and immunogenic RNA to sheep red blood cells. Three different routes of administration were used. The dose of 300 to 500 ug of immunogenic RNA injected intravenously of immunity to sheep red blood cells and Streptococcus pheumoniae in vivo were successful and comparable. The role of macrophages was determined by using cyclophosphamide which is toxic to lymphocytes but not to macrophages. The cyclophosphamide-treated mice when injected with sheep red blood cells failed to produce antibodies to sheep red blood cells. This indicated that the lymphocytes were affected and the ability to produce antibodies was impaired. Whereas, the immunogenic RNA obtained from the cyclophosphamide-treated mice transferred the ability to produce antibodies against sheep red blood cells. These results strongly suggest that the source of immunogenic RNA was mainly from the macrophages.
  note: by Vijaya Balusu Rao.
  note: "Major subject: Microbiology."
  note: Vita.
  note: Texas A & M University
  note: Includes bibliographical references (leaves 50-55).
  subject:
    topic: Immunoglobulins
  subject:
    topic: Immunology
    topic: Research
  subject:
    topic: RNA
  subject:
    topic: Major microbiology
  subject:
    topic: Immunoglobulins
  subject:
    topic: Immunology
    topic: Research
  subject:
    topic: RNA
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-358514
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-358514
  record info:
    record content source: TXA
    record creation date: 771003
    record change date: 20220103135420.0
    record identifier: in00000354445
    language of cataloging:
      language term: eng