rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Approaches to the total synthesis of vernolepin
  name:
    name part: Clement, Beverly Ann.
    role:
      role term: creator
  name:
    name part: Harding, K. E.
    role:
      role term: degree supervisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: txu
    date issued: 1978
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xvi, 208 leaves : illustrations ; 29 cm
  abstract: The basic goal of this study was the development of an efficient approach to the total synthesis of vernolepin. Special attention was paid to the development of an efficient synthesis of bicycle[4.3.1]-dec-3-en-9,10-diones 9 and the synthesis of various 4-alkoxycrotonates. [Figure1] The reaction of the morpholine enamine of 4-cycloheptenone with 4-allyloxycrotonyl chloride produced dione 46. Dione 46 was readily converted to enone 72 by treatment with phenyltrimethylammonium tribromide followed by dehydrohalogenation utilizing N,N-dimethylformamide, lithium carbonate and lithium bromide. Enone 72 was converted to enone 73 by treatment with ethylene glycol, benzene and a trace of p-toluenesulfonic acid. Enone 73 was readily converted to adduct 76, which is a bisnorvernolepin synthon, by utilization of a divinyl cuprate. [Figure2]
  note: by Beverly Ann Clement.
  note: "Major subject: Chemistry."
  note: Vita.
  note: Texas A & M University
  note: Includes bibliographical references (leaves 204-207).
  subject:
    topic: Antineoplastic agents
  subject:
    topic: Organic compounds
    topic: Synthesis
  subject:
    topic: Major chemistry
  subject:
    topic: Antineoplastic agents
  subject:
    topic: Organic compounds
    topic: Synthesis
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-235383
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-235383
  record info:
    record content source: TXA
    record creation date: 790816
    record change date: 20220103135402.0
    record identifier: in00000227697
    language of cataloging:
      language term: eng