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| LEADER |
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| 001 |
in00000044447 |
| 005 |
20220104090812.0 |
| 008 |
800607s1979 txu bm 000 0 eng d |
| 035 |
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|9 AAE8870AM
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| 035 |
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|a (OCoLC)06396780
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| 035 |
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|a (OCoLC)6396780
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| 035 |
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|a (OCoLC)ocm06396780
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| 040 |
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|a TXA
|b eng
|c TXA
|d OCLCQ
|d OCLCF
|d OCLCO
|d OCLCQ
|d UtOrBLW
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| 049 |
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|a TXAM
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| 099 |
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|a 1979
|a Dissertation
|a S116
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| 100 |
1 |
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|a Sabina, Richard Lee.
|0 http://id.loc.gov/authorities/names/n85830068
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| 245 |
1 |
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|a Regulation of nucleotide metabolism during conidial germination in Neurospora crassa.
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| 264 |
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1 |
|a [College Station, Tex.] :
|b Sabina,
|c 1979.
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| 300 |
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|a x, 54 leaves :
|b graphs ;
|c 29 cm
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a unmediated
|b n
|2 rdamedia
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| 338 |
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|a volume
|b nc
|2 rdacarrier
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| 500 |
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|a "Major subject: Genetics."
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| 500 |
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|a Vita.
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| 502 |
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|c Texas A & M University
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| 504 |
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|a Includes bibliographical references (leaves 46-52).
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| 520 |
3 |
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|a In order to investigate changes in nucleotide metabolism during a developmental change in fungus Neurospora crassa, intracellular nucleotide pools were determined b high pressure liquid chromatography before and during conidial germination. Wild type, as well as mutants blocked in de novo purine biosynthesis were used to characterize metabolic fluxes in the purine, pyrimidine, and histidine biosynthetic pathways which are known to be interrelated in Neurospora. These studies showed that the purine and pyrimidine biosynthetic pathways were active prior to and during germination, even when exogenous adenine was used to satisfy the auxotrophic requirement for purines in the mutant strains. However, in germinated conidia starved for adenine, large increases in all non-adenine containing nucleotides were found, showing that purine and pyrimidine biosynthesis are stimulated by the absence of an end-product, and also suggesting competition for the common substrate 5-phosphoribosyl-1-pyrophosphate (PRPP) limits the over-all rate of purine and pyrimidine biosynthesis. ...
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| 650 |
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0 |
|a Genetics.
|0 http://id.loc.gov/authorities/subjects/sh85053877
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| 650 |
|
0 |
|a Nucleotides
|x Metabolism.
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| 650 |
|
0 |
|a Purine nucleotides.
|0 http://id.loc.gov/authorities/subjects/sh85109188
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| 650 |
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0 |
|a Pyrimidine nucleotides.
|0 http://id.loc.gov/authorities/subjects/sh85109337
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| 650 |
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4 |
|a Major genetics.
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| 650 |
|
7 |
|a Genetics.
|2 fast
|0 (OCoLC)fst00940117
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| 650 |
|
7 |
|a Nucleotides
|x Metabolism.
|2 fast
|0 (OCoLC)fst01041120
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| 650 |
|
7 |
|a Purine nucleotides.
|2 fast
|0 (OCoLC)fst01084342
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| 650 |
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7 |
|a Pyrimidine nucleotides.
|2 fast
|0 (OCoLC)fst01084651
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| 655 |
|
7 |
|a Academic theses.
|2 lcgft
|0 http://id.loc.gov/authorities/genreForms/gf2014026039
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| 700 |
1 |
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|a Magill, Clint,
|e degree supervisor.
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| 700 |
1 |
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|a Magill, Jane M.,
|e degree committee member.
|0 http://id.loc.gov/authorities/names/n88262130
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| 700 |
1 |
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|a Smith, James D.,
|e degree committee member.
|0 http://id.loc.gov/authorities/names/n80050887
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| 700 |
1 |
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|a Wild, James R.,
|e degree committee member.
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| 710 |
2 |
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|a Texas A & M University,
|e degree granting institution.
|0 http://id.loc.gov/authorities/names/n80125885
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| 856 |
4 |
1 |
|u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=752364651&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
|z Link to ProQuest copy
|t 0
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| 856 |
4 |
1 |
|u https://hdl.handle.net/1969.1/DISSERTATIONS-53080
|z Link to OAKTrust copy
|t 0
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| 994 |
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|a C0
|b TXA
|
| 999 |
f |
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|s b2c939ed-7b76-3c91-827e-3ab9f53476c4
|i 4b870196-762c-3a23-b84d-a2d3e09c118d
|t 0
|
| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b J.J. Pickle Campus
|c High Density Repository
|s HDR
|d Remote Storage
|t 0
|e 1979 Dissertation S116
|h Other scheme
|i unmediated -- volume
|m A14840997066
|
| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1979 Dissertation S116
|h Other scheme
|
| 998 |
f |
f |
|a 1979 Dissertation S116
|t 0
|l Remote Storage
|
| 998 |
f |
f |
|a 1979 Dissertation S116
|t 0
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