Segmental mechanical properties of the canine thoracic aorta in vivo /

Bibliographic Details
Main Author: Gentile, Brian John, 1959-
Other Authors: Hightower, Dan (degree committee member.), Hunter, Jon F. (degree committee member.), Smith, Elvin E. (degree committee member.)
Format: Thesis Book
Language:English
Published: 1986.
Subjects:
Online Access:Link to ProQuest copy
Link to OAKTrust copy

MARC

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099 |a 1986  |a Disser-  |a tation  |a G338 
100 1 |a Gentile, Brian John,  |d 1959- 
245 1 0 |a Segmental mechanical properties of the canine thoracic aorta in vivo / 
264 1 |c 1986. 
300 |a x, 121 leaves :  |b illustrations ;  |c 29 cm 
336 |a text  |b txt  |2 rdacontent 
337 |a unmediated  |b n  |2 rdamedia 
338 |a volume  |b nc  |2 rdacarrier 
500 |a "Major subject: Veterinary Physiology." 
500 |a Typescript (photocopy). 
500 |a Vita. 
502 |b Ph. D.  |c Texas A & M University  |d 1986 
504 |a Includes bibliographical references (leaves 96-108). 
520 3 |6 520-00  |a The viscoelastic mechanical behavior of three well-defined segments of the canine thoracic aorta was described. These included segments of the ascending aorta (AA), the upper descending thoracic aorta (UDTA) and the middle descending thoracic aorta (MDTA). Ultrasonic dimension gauges and a catheter-tip manometer were used to measure changes in segment diameter, length and intravascular pressure during baseline, increased heart rate and increased pressure conditions. Change in segment volume (ΔV), a volumetric stiffness index (ΔP/ΔV) and a blood storage index (PΔV) were calculated for each segment during each condition. The ΔP/ΔV index significantly (α= 0.05) increased peripherally from the heart during baseline conditions. Average values from twelve dogs for ΔP/ΔV were 0.146 mmHg*mm^-3, 0.347 mmHg*mm^-3 and 0.739 mmHg*mm^-3 for the AA, UDTA and MDTA segments respectively. Longitudinal segment motion was a major factor in this increased stiffness. The total mean volume (V[T]), total change in volume (ΔV[T]) and a volumetric stiffness index (ΔP/ΔV[T]) were also calculated for the first two thirds of the thoracic aorta during baseline, increased heart rate and increased pressure conditions. The ΔP/ΔV[T] increased significantly (p < 0.03) from 10.7 mmHg*ml^-1 to 15.7 mmHg*ml^-1 using neosynephrine infusion. The first two thirds of the thoracic aorta contributes significantly to forward blood flow during diastole as determined by calculation of an average of 17% change in total volume for this segment in eight dogs. 
650 0 |a Aorta. 
650 0 |a Cardiovascular system  |x Research  |x Animal models. 
650 0 |a Dogs  |x Physiology. 
650 0 |a Thoracic arteries. 
650 4 |a Major veterinary physiology. 
655 7 |a Academic theses  |2 lcgft 
700 1 |a Gross, David R.,  |e degree supervisor. 
700 1 |a Hightower, Dan,  |e degree committee member. 
700 1 |a Hunter, Jon F.,  |e degree committee member. 
700 1 |a Smith, Elvin E.,  |e degree committee member. 
710 2 |a Texas A & M University,  |e degree granting institution. 
856 4 1 |u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=753963261&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD  |z Link to ProQuest copy  |t 0 
856 4 1 |u https://hdl.handle.net/1969.1/DISSERTATIONS-25075  |z Link to OAKTrust copy  |t 0 
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952 f f |p noncirc  |a Texas A&M University  |b J.J. Pickle Campus  |c High Density Repository  |s HDR  |d Remote Storage  |t 0  |e 1986 Dissertation G338  |h Other scheme  |i unmediated -- volume  |m A14839615407 
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