rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Pathogenesis and biological control of colibacillosis in chickens
  name:
    name part: Gyimah, Joseph Edmund
    name part: 1951-
    role:
      role term: creator
  name:
    name part: Fanguy, R. C.
    role:
      role term: degree committee member.
  name:
    name part: Grumbles, L. C.
    role:
      role term: degree committee member.
  name:
    name part: Hall, C. F.
    role:
      role term: degree committee member.
  name:
    name part: Panigraphy, Brundaban
    role:
      role term: degree supervisor.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: xx
    date issued: 1986
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiii, 96 leaves : illustrations ; 29 cm
  abstract: Specific attachment of E. coli (01:K1, 02:K1, 078:K80) to chicken tracheal epithelium was investigated using adherence inhibition studies. The role of pili as an adhesin was examined by blocking pili with antipilus antibodies. The nature of the host cell receptor was determined by blocking bacterial adhesion with specific carbohydrates or lectins and destroying the receptor with sodium metaperiodate. Antipilus antibodies to all 3 serotypes significantly (P [less than or equal to] 0.05) inhibited their adherence, an indication that pili serve as bacterial adhesins. Sodium metaperiodate significantly inhibited the adhesion of all 3 serotypes, suggesting a role for monosaccharides in the host cell receptor. D-mannose and its derivative methyl-α-D-mannopyranoside, inhibited the adhesion of serotypes 01 and 078, implying a role for these sugars in the host cell receptor. This was confirmed by the inhibition of both serotypes following treatment of tracheal epithelial cells with concanavalin A. None of the sugars or lectins used inhibited adhesion of serotype 02. Abrogation of pilus-mediated adhesion by antibodies directed against the pilus was investigated in chickens vaccinated with an oil-emulsified E. coli pilus vaccine against homologous challenge. Compared with positive control chickens, vaccinated chickens were protected against challenge because they suffered low or no mortality, had mild gross lesions, and eliminated challenge E. coli from tissues more efficiently. Protection was still evident when pili from all 3 serotypes were combined as a multivalent vaccine. Immunogenicity of E. coli (01:K1) whole cell bacterin was also evaluated in chickens. Against homologous challenge, vaccinated chickens were protected against active respiratory infection and also eliminated E. coli (01:K1) from tissues more efficiently than positive controls. However E. coli (01:K1) whole cell bacterin did not provide cross-protection against other pathogenic serotypes (02, 078). The re…
  note: "Major subject: Veterinary Microbiology."
  note: Typescript (photocopy).
  note: Vita.
  note: Ph. D. Texas A & M University 1986
  note: Includes bibliographical references (leaves 85-95).
  subject:
    topic: Escherichia coli infections
  subject:
    topic: Poultry
    topic: Diseases
    topic: Research
  subject:
    topic: Major veterinary microbiology
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-22342
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-22342
  record info:
    record content source: TXA
    record creation date: 880520
    record change date: 20220104090818.0
    record identifier: in00000015961
    language of cataloging:
      language term: eng