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| 001 |
in00000010357 |
| 005 |
20220104090718.0 |
| 008 |
880304s1986 xx a bm 000 0 eng d |
| 035 |
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|9 AAA2561AM
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| 035 |
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|a (OCoLC)17577344
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| 035 |
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|a (OCoLC)ocm17577344
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| 040 |
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|a TXA
|b eng
|c TXA
|d OCLCQ
|d OCLCO
|d TXA
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| 049 |
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|a TXAM
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| 099 |
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|a 1986
|a Disser-
|a tation
|a C689
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| 100 |
1 |
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|a Cole, Gregory Michael.
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| 245 |
1 |
4 |
|a The refined structure of elastase and molecular modelling software /
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| 264 |
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1 |
|c 1986.
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| 300 |
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|a xi, 255 leaves :
|b illustrations ;
|c 29 cm
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
|
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|a unmediated
|b n
|2 rdamedia
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| 338 |
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|a volume
|b nc
|2 rdacarrier
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| 500 |
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|a "Major subject: Biochemistry."
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| 500 |
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|a Typescript (photocopy).
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| 500 |
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|a Vita.
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| 502 |
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|b Ph. D.
|c Texas A & M University
|d 1986
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| 504 |
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|a Includes bibliographical references (leaves 180-185).
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| 520 |
3 |
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|a A system of macromolecular modelling programs for use on a PDP 11/40 with a Vector General II display device is described. The system allows the user to model interactions between large and small molecules and assists in interpretation of crystallographic electron density maps. The structure of porcine pancreatic elastase (PPE) has been refined using data to 1.65 Angstroms to an R-factor of 17.4% using the aforementioned software system. The details and results of that refinement are reported. The substrate binding site of PPE is compared to those of bovine trypsin and porcine kallikrein with the objective of delineating the role played by the various residues of the binding site in determining the specificity of PPE.
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| 650 |
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0 |
|a Crystallography
|x Data processing.
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| 650 |
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0 |
|a Elastases.
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| 650 |
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0 |
|a Protein binding
|x Data processing.
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| 650 |
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4 |
|a Major biochemistry.
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| 655 |
|
7 |
|a Academic theses
|2 lcgft
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| 700 |
1 |
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|a Gunn, John Martyn,
|e degree committee member.
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| 700 |
1 |
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|a Meyer, Edgar,
|e degree supervisor.
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| 700 |
1 |
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|a Pace, Carlos N.,
|e degree committee member.
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| 700 |
1 |
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|a Scott, Alister Ian,
|e degree committee member.
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| 710 |
2 |
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|a Texas A & M University,
|e degree granting institution.
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| 856 |
4 |
1 |
|u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=749104201&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
|z Link to ProQuest copy
|t 0
|
| 856 |
4 |
1 |
|u https://hdl.handle.net/1969.1/DISSERTATIONS-16433
|z Link to OAKTrust copy
|t 0
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| 994 |
|
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|a C0
|b TXA
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| 999 |
f |
f |
|s d9958390-520e-3746-a3a4-3611f5f123a4
|i 651ff270-304c-3eb1-affa-5e27b18f6419
|t 0
|
| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b J.J. Pickle Campus
|c High Density Repository
|s HDR
|d Remote Storage
|t 0
|e 1986 Dissertation C689
|h Other scheme
|i unmediated -- volume
|m A14839618497
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| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1986 Dissertation C689
|h Other scheme
|
| 998 |
f |
f |
|a 1986 Dissertation C689
|t 0
|l Remote Storage
|
| 998 |
f |
f |
|a 1986 Dissertation C689
|t 0
|l Available Online
|