The refined structure of elastase and molecular modelling software /

Bibliographic Details
Main Author:	Cole, Gregory Michael
Other Authors:	Gunn, John Martyn (degree committee member.), Pace, Carlos N. (degree committee member.), Scott, Alister Ian (degree committee member.)
Format:	Thesis Book
Language:	English
Published:	1986.
Subjects:	Crystallography > Data processing. Elastases. Protein binding > Data processing. Major biochemistry. Academic theses
Online Access:	Link to ProQuest copy Link to OAKTrust copy

Description
Abstract:	A system of macromolecular modelling programs for use on a PDP 11/40 with a Vector General II display device is described. The system allows the user to model interactions between large and small molecules and assists in interpretation of crystallographic electron density maps. The structure of porcine pancreatic elastase (PPE) has been refined using data to 1.65 Angstroms to an R-factor of 17.4% using the aforementioned software system. The details and results of that refinement are reported. The substrate binding site of PPE is compared to those of bovine trypsin and porcine kallikrein with the objective of delineating the role played by the various residues of the binding site in determining the specificity of PPE.
Item Description:	"Major subject: Biochemistry." Typescript (photocopy). Vita.
Physical Description:	xi, 255 leaves : illustrations ; 29 cm
Bibliography:	Includes bibliographical references (leaves 180-185).