rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Fescue induced inhibition of prolactin secretion
    sub title: development of a rat model
  name:
    name part: Manning, Walter Scott
    name part: 1945-
    role:
      role term: creator
  name:
    name part: Amoss, Max S.
    role:
      role term: degree committee member.
  name:
    name part: Bratton, Gerald
    role:
      role term: degree supervisor.
  name:
    name part: McArthur, Newell
    role:
      role term: degree committee member.
  name:
    name part: Scott, George G.
    role:
      role term: degree committee member.
  name:
    name part: Sis, Raymond F.
    role:
      role term: degree committee member.
  name:
    name part: Texas A & M University
    role:
      role term: degree granting institution.
  type of resource: text
  genre: bibliography
  genre: Academic theses
  origin info:
    place:
      place term: xx
    date issued: 1986
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xiv, 194 leaves : illustrations ; 29 cm
  abstract: Effects of Kentucky-31 endophyte-infected seed extract (KEISE) on serum and plasma prolactin (PRL), on hypophyseal concentrations of PRL and the ultrastructure of hypophyseal and mammary glands were investigated. Timebred Sprague-Dawley rats received chronic levels of KEISE or PSS over a period of 10 d. The KEISE-treated dams did not produce a rise in serum PRL after whelping and were agalactic. Pups were either stillborn or small and weak and usually starved to death. PSS-treated dams produced normal, elevations in serum PRL after whelping, supplying copious amounts of milk to large, healthy litters. Student's T test indicated no difference between control and treated rats on d 16 and 13 and differences on d 20, 22, 24 and 26. Dunnett's test indicated treatment means for control rats differed from control means all days except d 16. Treatment means for KEISE-treated rats did not dif fer from control mean. Non-pregnant rats with heterogeneous hypophyseal grafts (HAG) were used to produce artificially high levels of PRL to observe the effects of KEISE on plasma PRL. A single dose of 4.86 gram seed equivalents/milliliter (g sd eg/ml) of KEISE produced a decrease in PRL for 3 to 6 h, then rebounded to the original zero levels. Plasma PRL in PSS-treated rats remained constant throughout the experiment. The pattern across time differed significantly (P<.05) A dose response using PRL and KEISE was observed in the HAG rats. Plasma PRL levels decreased as a linear function of increasing KEISE dose levels (30 min: P<0.03 and 60 min: P<0.01). Prolactin was immunocytochemically stained in hypophyseal tissue and evaluated with a microspectrophotometer. Absorbance in KEISE-treated animals was 22% while PSS-treated animals absorbed 37%, a substantial difference at the 95% confidence level. Hypophyseal and mammary tissues from KEISE and PSS-treated synchronized-bred nursing rats were studied ultrastructurally. PRL-producing cells from KEISE-treated rats showed decreased rough endo…
  note: "Major subject: Veterinary Anatomy."
  note: Typescript (photocopy).
  note: Vita.
  note: Ph. D. Texas A & M University 1986
  note: Includes bibliographical references (leaves 164-193).
  subject:
    topic: Cattle
    topic: Diseases
  subject:
    topic: Forage plants
    topic: Toxicology
  subject:
    topic: Prolactin
  subject:
    topic: Tall fescue
  subject:
    topic: Major veterinary anatomy
  identifier: http://proxy.library.tamu.edu/login
  identifier: https://hdl.handle.net/1969.1/DISSERTATIONS-16948
  related item:
    location:
      url: http://proxy.library.tamu.edu/login
  related item:
    location:
      url: https://hdl.handle.net/1969.1/DISSERTATIONS-16948
  record info:
    record content source: TXA
    record creation date: 880314
    record change date: 20220104090822.0
    record identifier: in00000009029
    language of cataloging:
      language term: eng