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00000ctm a2200000Ia 4500 |
| 001 |
in00000009029 |
| 005 |
20220104090822.0 |
| 008 |
880314s1986 xx a bm 000 0 eng d |
| 035 |
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|9 AAA3100AM
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| 035 |
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|a (OCoLC)17625675
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| 035 |
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|a (OCoLC)ocm17625675
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| 040 |
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|a TXA
|b eng
|c TXA
|d OCLCQ
|d OCLCO
|d TXA
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| 049 |
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|a TXAM
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| 099 |
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|a 1986
|a Disser-
|a tation
|a M284
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| 100 |
1 |
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|a Manning, Walter Scott,
|d 1945-
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| 245 |
1 |
0 |
|a Fescue induced inhibition of prolactin secretion :
|b development of a rat model /
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| 264 |
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|c 1986.
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| 300 |
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|a xiv, 194 leaves :
|b illustrations ;
|c 29 cm
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a unmediated
|b n
|2 rdamedia
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| 338 |
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|a volume
|b nc
|2 rdacarrier
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| 500 |
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|a "Major subject: Veterinary Anatomy."
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| 500 |
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|a Typescript (photocopy).
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| 500 |
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|a Vita.
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| 502 |
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|b Ph. D.
|c Texas A & M University
|d 1986
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| 504 |
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|a Includes bibliographical references (leaves 164-193).
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| 520 |
3 |
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|a Effects of Kentucky-31 endophyte-infected seed extract (KEISE) on serum and plasma prolactin (PRL), on hypophyseal concentrations of PRL and the ultrastructure of hypophyseal and mammary glands were investigated. Timebred Sprague-Dawley rats received chronic levels of KEISE or PSS over a period of 10 d. The KEISE-treated dams did not produce a rise in serum PRL after whelping and were agalactic. Pups were either stillborn or small and weak and usually starved to death. PSS-treated dams produced normal, elevations in serum PRL after whelping, supplying copious amounts of milk to large, healthy litters. Student's T test indicated no difference between control and treated rats on d 16 and 13 and differences on d 20, 22, 24 and 26. Dunnett's test indicated treatment means for control rats differed from control means all days except d 16. Treatment means for KEISE-treated rats did not dif fer from control mean. Non-pregnant rats with heterogeneous hypophyseal grafts (HAG) were used to produce artificially high levels of PRL to observe the effects of KEISE on plasma PRL. A single dose of 4.86 gram seed equivalents/milliliter (g sd eg/ml) of KEISE produced a decrease in PRL for 3 to 6 h, then rebounded to the original zero levels. Plasma PRL in PSS-treated rats remained constant throughout the experiment. The pattern across time differed significantly (P<.05) A dose response using PRL and KEISE was observed in the HAG rats. Plasma PRL levels decreased as a linear function of increasing KEISE dose levels (30 min: P<0.03 and 60 min: P<0.01). Prolactin was immunocytochemically stained in hypophyseal tissue and evaluated with a microspectrophotometer. Absorbance in KEISE-treated animals was 22% while PSS-treated animals absorbed 37%, a substantial difference at the 95% confidence level. Hypophyseal and mammary tissues from KEISE and PSS-treated synchronized-bred nursing rats were studied ultrastructurally. PRL-producing cells from KEISE-treated rats showed decreased rough endoplasmic reticulum (RER), Golgi apparatus (GA), ribosomes and immature and mature secretory granules compared to control cells. The mammary gland in KEISE-treated rats contained noticeable differences in RER and GA when compared to controls and secretory vesicles increased confirming a lack of secretion.
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| 650 |
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|a Cattle
|x Diseases.
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| 650 |
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|a Forage plants
|x Toxicology.
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| 650 |
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|a Prolactin.
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| 650 |
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0 |
|a Tall fescue.
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| 650 |
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4 |
|a Major veterinary anatomy.
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| 655 |
|
7 |
|a Academic theses
|2 lcgft
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| 700 |
1 |
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|a Amoss, Max S.,
|e degree committee member.
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| 700 |
1 |
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|a Bratton, Gerald,
|e degree supervisor.
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| 700 |
1 |
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|a McArthur, Newell,
|e degree committee member.
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| 700 |
1 |
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|a Scott, George G.,
|e degree committee member.
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| 700 |
1 |
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|a Sis, Raymond F.,
|e degree committee member.
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| 710 |
2 |
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|a Texas A & M University,
|e degree granting institution.
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| 856 |
4 |
1 |
|u http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=749099171&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD
|z Link to ProQuest copy
|t 0
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| 856 |
4 |
1 |
|u https://hdl.handle.net/1969.1/DISSERTATIONS-16948
|z Link to OAKTrust copy
|t 0
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| 994 |
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|a C0
|b TXA
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| 999 |
f |
f |
|s f647e216-edd7-3e0b-ad49-4fa7b0839ab4
|i 4d106e28-c531-3e35-896a-9101cdac5ff6
|t 0
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| 952 |
f |
f |
|p noncirc
|a Texas A&M University
|b J.J. Pickle Campus
|c High Density Repository
|s HDR
|d Remote Storage
|t 0
|e 1986 Dissertation M284
|h Other scheme
|i unmediated -- volume
|m A14839614639
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| 952 |
f |
f |
|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e 1986 Dissertation M284
|h Other scheme
|
| 998 |
f |
f |
|a 1986 Dissertation M284
|t 0
|l Available Online
|
| 998 |
f |
f |
|a 1986 Dissertation M284
|t 0
|l Remote Storage
|